The solution offered by the world for the suffering from mental illness is predominantly a biochemical, pharmaceutical one. This is expected when mental illness is understood as a biological issue. But what if mental illness is predominantly a spiritual, relational issue? Then the solutions offered would be suddenly quite different. In fact, to deal with all the issues of sin and suffering of the human soul and spirit, the ultimate and only solution would then be Christ and the power of the cross. By “shifting the ground” and changing the entire context of mental suffering, it seems that the world has rendered the cross powerless, Christ more or less irrelevant and confused Christians with complex medical terminology and concepts. The Church could do well to reclaim fully the “care and cure” of souls. This message was a part of seminar series on mental health and depression. The Scriptures, especially the Psalms, relate to the deepest emotions and suffering of the human soul and spirit.